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WKYMVM 2TFA(187986-17-0(free base))
CAS No. ——
WKYMVM 2TFA(187986-17-0(free base)) ( —— )
产品货号. M22772 CAS No. ——
WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells.Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVm, WKYMVm receptor and bactericidal activity did not differ between patients and controls.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3634 | 有现货 |
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| 10MG | ￥6069 | 有现货 |
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| 50MG | 获取报价 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称WKYMVM 2TFA(187986-17-0(free base))
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells.Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVm, WKYMVm receptor and bactericidal activity did not differ between patients and controls.
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产品描述WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells.Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVm, WKYMVm receptor and bactericidal activity did not differ between patients and controls.Addition of WKYMVm markedly increased the bactericidal activities of these cells in a dose-dependent manner.During induction chemotherapy, there were significant increases in bactericidal activity in the presence and absence of 1nM WKYMVm, with higher bactericidal activities at the time of complete remission than at the time of diagnosis or on day 15.During consolidation chemotherapy, WKYMVm had no effect on bactericidal activities.Patients showed significant increase in the concentrations of TNF alpha, IL-1b, IL-6 and IL-8, but significant decrease in the concentrations of IL-2, IL-4 and IL-12.TNF alpha, IL-1b and IL-6 showed significant negative correlations with bactericidal activities of patient neutrophils at time of diagnosis, and IL-4 showed a significant positive correlation with bactericidal activities,these findings indicate that WKYMVm enhances bactericidal activity in patients with AL.
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同义词——
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通路Others
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靶点Other Targets
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受体FPR1
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量856.11
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分子式C41H61N9O7S2
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纯度>98% (HPLC)
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溶解度——
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SMILESOC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Christophe T , Karlsson A , Dugave C , et al. The Synthetic Peptide Trp-Lys-Tyr-Met-Val-Met-NH2 Specifically Activates Neutrophils through FPRL1/Lipoxin A4 Receptors and Is an Agonist for the Orphan Monocyte-expressed Chemoattractant Receptor FPRL2[J]. Journal of Biological Chemistry, 2001, 276(24):21585-21593.
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