WKYMVM 2TFA(187986-17-0(free base))

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

WKYMVM 2TFA 是一种 N-甲酰肽受体 (FPR1) 激动剂。WKYMVM 通过 FPRL1 激活中性粒细胞，而 FPRL2 是骨髓细胞中转导信号的趋化受体。使用从 28 名 AL 患者和 31 名健康对照中抽取的血液样本发现，在没有外源性 WKYMVm 的情况下，患者和对照组之间的 WKYMVm 受体和杀菌活性没有差异。

WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells.Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVm, WKYMVm receptor and bactericidal activity did not differ between patients and controls.?Addition of WKYMVm markedly increased the bactericidal activities of these cells in a dose-dependent manner.?During induction chemotherapy, there were significant increases in bactericidal activity in the presence and absence of 1nM WKYMVm, with higher bactericidal activities at the time of complete remission than at the time of diagnosis or on day 15.?During consolidation chemotherapy, WKYMVm had no effect on bactericidal activities.?Patients showed significant increase in the concentrations of TNF alpha, IL-1b, IL-6 and IL-8, but significant decrease in the concentrations of IL-2, IL-4 and IL-12.?TNF alpha, IL-1b and IL-6 showed significant negative correlations with bactericidal activities of patient neutrophils at time of diagnosis, and IL-4 showed a significant positive correlation with bactericidal activities,these findings indicate that WKYMVm enhances bactericidal activity in patients with AL.

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Others

Other Targets

FPR1?

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856.11

C41H61N9O7S2

>98% (HPLC)

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OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years